High-Affinity Anion Binding by Steroidal Squaramide Receptors
نویسندگان
چکیده
منابع مشابه
High-Affinity Anion Binding by Steroidal Squaramide Receptors**
Exceptionally powerful anion receptors have been constructed by placing squaramide groups in axial positions on a steroidal framework. The steroid preorganizes the squaramide NH groups such that they can act cooperatively on a bound anion, while maintaining solubility in nonpolar media. The acidic NH groups confer higher affinities than previously-used ureas or thioureas. Binding constants exce...
متن کاملSynthetically accessible, high-affinity phosphate anion receptors.
We report synthetically accessible receptors with protonated amines attached to a conformationally constrained backbone including amide units, and demonstrate that these receptors have high affinities (log K > 5) for phosphate anions in aqueous media at pH 7 in the presence of high concentrations of competitive chloride anions (ca. 100-fold excess).
متن کاملSquaramide-based tripodal receptors for selective recognition of sulfate anion.
Squaramide-based tripodal anion receptors have been prepared and their anion binding properties with various inorganic anions were investigated. Receptor formed a dimeric complex in solid state and a 1 : 1 complex in solution with SO(4)(2-). All receptors could selectively encapsulate SO(4)(2-)via hydrogen bonds over other examined anions.
متن کاملMacrocyclic squaramides: anion receptors with high sulfate binding affinity and selectivity in aqueous media
School of Chemistry, The University of Sydn [email protected]; Fax: +61 2 935 † Electronic supplementary information (E H and C NMR spectra, titration data, spectra. CCDC 1457412–1457415. For ES other electronic format see DOI: 10.1039/ ‡ Current address: Department of Chem University of Ireland Maynooth, Co. Ki nuim.ie; Fax: +353 1708 3815; Tel.: +353 1 Cite this: Chem. Sci., 2016, 7...
متن کاملHigh-affinity binding of [3H]acetylcholine to muscarinic cholinergic receptors.
High-affinity binding of [3H]acetylcholine to muscarinic cholinergic sites in rat CNS and peripheral tissues was measured in the presence of cytisin, which occupies nicotinic cholinergic receptors. The muscarinic sites were characterized with regard to binding kinetics, pharmacology, anatomical distribution, and regulation by guanyl nucleotides. These binding sites have characteristics of high-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2015
ISSN: 1433-7851
DOI: 10.1002/anie.201411805